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Michael G. Douglas, Ph.D.
Professor & Director UAMS Bioventures
Ph.D., St. Louis University
Organelle
Function and Entrepreneurialism
My research interests center on
the participation of mitochondria in the growth control circuitry of the cell.
Collaborative research studies address the organelle-dependent regulation
of different signaling events and the consequences of mutations within the
mitochondrial genome. More recent studies
address the mechanisms of age-dependent mitochondrial loss of function and how
this affects the partitioning of growth regulatory proteins and metabolites
between the organelle and other subcellular compartments.
Current collaborative projects involve the consequences of aging and
oncogenesis with organelle genome dynamics and function.
Earlier work from my laboratory addressed the mechanisms of cytoplasm
protein sorting, organelle protein delivery and the cellular machinery which
participates in the control of protein folding and assembly.
In addition to these research interests I
have developed a program within the UAMS graduate curriculum which is focused on
the entrepreneurial training of the biomedical scientist.
The focus of the program will be on exposing students to the basics of
the entrepreneurial process involving patents, consulting, research and license
agreements and the importance of these to the independent scientist.
The idea is to expand through knowledge of the commercialization process,
the opportunities available to the student, post-doctoral fellow or independent
investigator. In my role as Director of UAMS
BioVentures®, I am responsible for the patenting and licensing of discovery from
UAMS and the operation of a wet laboratory incubator within the University.
This resource provides interested investigators the opportunity to
leverage the resources of BioVentures® and develop more applied research funding
opportunities for translational research that develops as part of their basic
discovery.
Selected Publications
Krimmer, T., Rapaport, D., Ryan, M., Meisinger, C., Kassenbrock, K., Forte, M.,
Douglas, M. G., Neupert, W., Nargang, F. and Pfanner, N. (2001) Biogenesis of
the major outer membrane protein porin involves a complex import pathway via
receptors and the general import pore. J. Cell Biol. 152, 289-300
Matabashi, T., Takeda, M. and Douglas, M. G. (2000) ASC1/RAS2 suppresses the
growth-defect on glycerol caused by atp1-2 mutation in yeast. J Biol Chem. 275,
10492-10497
Pfanner,
N., Douglas, M.G., Endo, T., Hoogenroad, N., Jensen, R., Meijer, M., Neupert,
W., Schatz, G., Schmitz, U. and Shane, G. (1996) Uniform Nomenclature for
Protein Transport Machinery of the Mitochondrial Membranes, Trends in Biochem.
Sci. 21, 51-52.
Kassenbrock CK. Gao G. J. Groom KR.
Sulo P.
Douglas, M.G. Martin NC. (1995) RPM2, independently of its mitochondrial Rnase P
function, suppressed an ISP42 mutant defective in mitochondrial import and is
essential for normal growth. Mol. Cell Biol. 15(9):4763-70.
Cao,
W., and Douglas, M.G. (1995) Biogenesis of ISP6, a small carboxy-terminal
anchored protein of the receptor complex of the mitochondrial outer membrane.
J. Biol. Chem. 270(10):5674-9.
Caplan,
A.J., Cyr, D.M. and Douglas, M.G. (1992) YDJ1p facilitates polypeptide
translocation across different intracellular membranes by a
conserved mechanism. Cell 71, 1143-1156.
Harrington, K., and Douglas,
M.G. (2006) Cross Campus Entrepreneurship: Organizing within Washington
University to Create an Innovative Environment. J. Technology Transfer 32, in
press
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E-mail: |
MDouglas@uams.edu |
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Office: |
501-686-6696
Lab |
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Lab: |
501-686-8927 Office |
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FAX: |
501-686-8501 |
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