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Projects 1) Neonatal Pain and Stress: To evaluate the effect of neonatal pain and stress on functional and neurophysiological outcomes in the adult. The studies examine the neuroplasticipity and behavioral changes in adult rodents, associated with neonatal exposure to painful stimuli and evaluate appropriate environmental, pharmacological and alternative interventions to prevent and reduce the long-term effects of neonatal pain. 2) Gender and Pain: To examine gender-related differences in the processing of pain. The studies look carefully at the role of sex hormones in the somatic and visceral sensitivity in rodents. 3) Functional Pain: These studies are designed around an etiology of sensitization in functional pain. They examine the role of neonatal injury in the development of functional pain and appropriate conventional and alternative means to reverse these pains. 4) Irritable Bowel Syndrome (IBS): Irritable bowel syndrome is a functional bowel disorder of the gastrointestinal (GI) tract characterized by recurrent abdominal pain and discomfort accompanied by alterations in bowel function, diarrhea, constipation or a combination of both, typically over months or years. Our “IBS Project” is aimed at understanding the underlying causes of the persistent symptoms of IBS and trying to reverse them. The project is in part, collaboration between ACELAB and a number of pharmaceutical companies. 5) Neuronal Pathways of Pain: This project examines the molecular, cellular and system pathways involved in the processing of pain.
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