Translational Research Institute

Translational Research

The TRI defines translational science as that which transforms scientific discoveries arising from laboratory, clinical, or population studies into clinical applications to reduce disease incidence, morbidity, and mortality. Translational research occurs on a bi-directional continuum of T1 through T4 research that addresses human health questions and creates human health interventions.

• T1 research jump-starts the process of translation of bench research to the patient bedside, generally in a limited fashion. This is where basic science discoveries directly related to human health, case study/pilot clinical research, and Phase 1 and 2 clinical trials usually occur.
• T2 expands that sphere of discovery to larger patient populations in Phase 3 and 4 clinical trials, observational studies, or survey research in target populations. New discoveries can result in need for more translational research in basic sciences (T2T1) or influence T3 research (T2T3).
• T3, the practice-oriented stage of translational science, uses dissemination and implementation research to answer such questions as: Is treatment X actually being used in the community-at-large, and if not, why not? The identification of new clinical questions, barriers, and gaps in care related to treatment X is focused on at this stage.
• If T1 T3 studies reach their goals and data indicate efficacious practices or results, new policy or outcomes research is engendered in T4. Do existing laws or policies for insurance reimbursement allow equal access or implementation of treatment X to target populations? Is treatment X more effective or of equal effectiveness than other standard of care practices?

UAMS Translational Research Institute
4301 W. Markham #Slot 577, Little Rock, AR 72205, 501-614-2287


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