Translational Sciences Faculty
Track Leader-William D.
Sameh R. Abul-Ezz, M.D., Dr.P.H. (Nephrology)
My current research interests include early kidney transplant function and the development of urinary biomarkers for early detection of acute kidney failure and acute rejection.
Aline Andres, Ph.D. (Pediatrics)
Our research program is centered around the
prevention of diseases through the optimization of early nutrition. We are
particularly focused on fetal and neonatal programming of obesity. Our
translational approach seek to understand the mechanisms underlying obesity
programming and develop strategies to prevent it.
Alexei G. Basnakian, M.D., Ph.D. (Pharmacology and Toxicology)
My interests are both in translational research and basic science. In translational research, my team studies on the role of carbamylated LDL (cLDL) in atherosclerosis that occurs in patients with chronic renal failure (CRF) and smokers. Our studies show that cLDL induces pro-atherosclerotic injuries in cultured vascular endothelial and smooth muscle cells, as well as in ApoE knockout mice with CRF. Plasma cLDL elevation is associated with atherosclerosis in CRF patients and tobacco smokers. In basic science, we study the role of cytotoxic endonucleases (CEs) in a variety of tissue injuries. Our data strongly indicate that DNA fragmentation by endogenous CEs is the key mechanism of irreversible cell death in all cells and tissues.
Cornelia Beck, Ph.D. (Geriatrics)
focuses on delaying functional decline and dealing with behavioral symptoms
in persons with Alzheimer's disease. Our interventions involve capitalizing
on the person's remaining strengths and individualizing behavioral and
Sarah Blossom, Ph.D. (Pediatrics)
Blossom is an immunologist working in the area of immunotoxicology and reproductive immunology. Her research uses a mouse model to study the neuroimmune modulation caused by maternal and early life exposure to toxicants such as trichloroethylene and cigarette smoke. Understanding the immunologic basis and environmental triggers involved in the etiology of neurologic disorders could be crucial for the development of effective screening, therapeutic, and preventive strategies for human disorders. Dr. Blossom also conducts research within the Section of Birth Defects Research by studying the role of the maternal immune response and congenital heart defects in humans.
Puran Bora, Ph.D. (Opthalmology)
Age Related Macular Degeneration (AMD), an eye disease which can cause loss of central vision in the population over the age of 50. Our laboratory is studying the Molecular and Biochemical mechanisms of AMD and uvietis
in order to find a cure and/or prevention of the diseases.
Elizabeth Ann Coleman, Ph.D., R.N. (Nursing Sciences)
Symptom management and supportive care, familial risk of cancer
Mario Cleves, Ph.D. (Pediatrics)
Current research interests focus on discerning the genetic and environmental causes of major structural congenital malformations, particularly neural tube and congenital heart defects, and the assessment of qualify of pediatric health services and interventions to modify health care provider behavior.
Marsha Eigenbrodt, M.D., M.P.H. (Cardiology) Web profile
As a pathologist and epidemiologist, I have broad interests in chronic diseases with a particular interest in the methodological issues facing observational and clinical studies. Specific interests include indicators of arteriosclerosis severity and vascular aging, gene-environmental interactions, orthostatic hypotension, stroke, the relationship between alcohol and cardiovascular disease, and novel vascular risk factors in renal disease.
and Developmental Sciences)
of the reticular activating system and sleep, schizophrenia, depression, PTSD,
spinal cord injury.
W. Brooks Gentry, M.D. (Anesthesiology, Pharmacology and
Our goal is to develop
antibody-based medications for stimulant abuse, which alter the
pharmacokinetic properties of these drugs. These studies are part of a
multidisciplinary, clinician scientist approach to the rational development
of therapeutic strategies, and provide the background information necessary
for translational research of the efficacy of antibody-based medications for
the treatment of human drug abuse.
Robert J. Griffin, Ph.D. (Radiation
Oncology) Web profile
The radiation biology group led by Dr. Griffin investigate molecular and physiological mechanisms of radiation and thermal sensitization of solid tumors; modulation of tumor blood flow, angiogenesis and oxygenation; and oxygen partial pressure as a predictor of cancer treatment outcomes. In addition, research projects are being performed with nanoparticles to target the tumor microenvironment or assist other therapy in achieving tumor destruction. In all aspects of our work, the influence of contact between tumor cells and stromal cells, such as endothelial, smooth muscle or fibroblast cells on cancer biology and treatment response is also being studied to understand the importance of cell-cell crosstalk and mechanisms of bystander cell communication and responses.
Martin Hauer-Jensen, M.D., Ph.D. (Interdisciplinary Biomedical
Sciences) Web profile
Radiation biology; gastrointestinal pathophysiology; endothelial biology
Howard Hendrickson, Ph.D. (Pharmaceutical Sciences) Web profile
Jack Hinson, Ph.D. (Pharmacology and Toxicology)
Charlotte Hobbs, M.D., Ph.D. (Pediatrics, Epidemiology)
Our team's research interests include genetic epidemiology, congenital heart defects, genomics, oxidative stress, folate-related pathways, diabetes, obesity, and prematurity.
Andrew James, Ph.D. (Psychiatry)
Dr. Andrew James is an assistant professor at the Brain Imaging Research Center (BIRC) in the Department of Psychiatry. His research uses novel functional neuroimaging paradigms to explore the impact of individual variability upon brain networks encoding cognition (such as attention and executive function). He seeks to develop a large, normative functional MRI database to improve the translational impact of functional neuroimaging in clinical care.
Laura James, M.D. (Interdisciplinary
Toxicology) Web profile
Dr. Laura James is Principal
Investigator for the Pediatric Pharmacology Research Unit at Arkansas
Children's Hospital. Her research emphasis in the basic sciences is in understanding
mechanisms of repair for hepatotoxins (acetaminophen, chloroform) in the
mouse model. She is also interested in the detection of biomarkers of
acetaminophen toxicity (acetaminophen protein adducts) in clinical samples
and their correlation with clinical endpoints.
Clint Kilts, Ph.D. (Psychiatry)
Dr. Kilts is the founding Director of the Brain Imaging Research Center (BIRC) in the new UAMS Psychiatric Research Institute (PRI) and an Associate Director of the PRI. Dr. Kilts has a long record of NIH-funded research, most recently in the use of in vivo brain functional, molecular and connectivity imaging to explore the neural network processing basis of human behavior. With a focus on drug abuse and addiction, he has a clinical research focus on the use of neuroimaging technology to define the brain basis of psychiatric disorders and their treatment.
Louanne Lawson, Ph.D., R.N.,
FAAN, DF-IAFN (Nursing
Child abuse prevention
Kim E. Light, Ph.D. (Pharmaceutical
program is aimed at developing neuronal systems and the alterations to
development that result subsequent to exposures to alcohol and other drugs. Our
current approach involves immunofluorescence labeling of specific cellular
structures, at various developmental times, followed by confocal microscopy
analysis of structural neuronal features characteristic of normal developmental
as well as specific drug-induced alterations.
Curtis Lowery M.D. (Obstetrics
Dr. Lowery leads the Fetal Instrumentation Group (FIG), a collaborative effort between UAMS and UALR to develop newer more accurate methods of maternal-fetal assessment. Through an active research program the FIG has designed and developed several novel instruments and conducted clinical studies on the fetus. His efforts to develop a completely non-invasive maternal-fetal physiograph resulted in NIH funding to construct the first fetal MEG system called SARA (SQUID Array for Reproductive Assessment). Dr. Lowery has created three model telemedicine programs. The Antenatal & Neonatal Guidelines, Education and Learning System (ANGELS) is a high-risk pregnancy consultation service delivering never-before-available care in rural Arkansas. The Center for Distance Health offers rural Arkansas access to all medical specialties through telemedicine. Arkansas Telehealth Oversight and Management (ATOM) is a statewide consortium of healthcare providers aimed at improving service delivery in rural Arkansas through telemedicine. Finally, Dr. Lowery is the PI of a major NIH Clinical and Translational Science Award (CTSA) to the UAMS campus.
Stewart MacLeod, Ph.D. (Pediatrics)
Molecular and cell biology
Lee Ann MacMillan-Crow, Ph.D. (Pharmacology and Toxicology)
Our laboratory has been investigating the role that increased mitochondrial oxidant production has on the early events leading to renal dysfunction following renal preservation and warm ischemia/reperfusion (I/R) in vivo. Previous studies have suggested that inactivation of the major antioxidant within the mitochondria, manganese superoxide dismutase (MnSOD), plays a pivotal role in inducing renal injury during I/R injury. Using both cell and rodent models we are also assessing the therapeutic potential of known and novel antioxidants to alter I/R and transplantation induced renal dysfunction.
Stavros Manolagas, M.D., Ph.D. (Internal Medicine)
Basic research into the interplay among hormones, cytokines, the hematopoietic/immune system and bone.
Bradley C. Martin, Pharm.D., Ph.D. (Pharmacy Practice) Web profile
Pharmaceutical Evaluation and Policy program investigates the impact
pharmaceutical products, policies, and services has on patient and system
Robert E. McGehee, Ph.D. (Pathology,
Physiology & Biophysics, Bioinformatics)
Molecular biology; adipocyte development; regulation of adipogenesis by retinoblastoma proteins
Jean McSweeney, Ph.D. (Nursing
Women and cardiovascular disease, focusing on early warning and acute symptoms
of myocardial infarction
Donald Mock, M.D., Ph.D. (Clinical Nutrition, Biochemistry and
Molecular Biology) Web profile
AREAS OF CURRENT RESEARCH INTEREST
1. Nutrition of Biotin- Incidence of biotin deficiency in pregnancy and potential role of biotin deficiency in human teratogenesis; biotin metabolism, particularly degradation and regulation of degradation of biotin; mechanism and regulation of cellular uptake including inborn errors of biotin transport; role of biotin in biotinylation of histones and their potential role on DNA replication or transcription.
2. Non-radioactive measurement of red cell mass and red cell survival.
3. Biotinylation of low molecular peptides hormones such as erythropoietin and subsequent quantitation in order to study pharmacokinetics of endogenously secreted erythropoietin and potentially other hormones
Jeffery Moran, Ph.D. (Pharmacology and Toxicology)
efforts focus on developing new metabolomic approaches which can help us better
understand adverse drug reactions and provide new therapeutic strategies.
Currently, we are studying phase I and II metabolism of warfarin and applying
this information to clinical applications by trying to understand the
relationship between warfarin metabolism and anticoagulant therapy outcomes.
Mayumi Nakagawa, M.D., Ph.D. (Pathology)
T cell immunity to human papillomavirus as it relates to the development of
therapeutic vaccines and immunotherapy.
Alison Oliveto, Ph.D. (Psychiatry and Behavioral Sciences)
Research interests include the phase I and II clinical trials focused primarily on the development of new medications and combinations of medication and behavioral interventions for the treatment of opioid and/or psychostimulant dependence and withdrawal.
S. Michael Owens, Ph.D. (Pharmacology,
Carmen T. Paniagua, Ed.D., RN,
MSN, APN, ACNP-BC (Nursing Science)
Research interest in the translation of genetics/genomics into clinical practice and cancer genetics. Current research is on the identification of genes for the susceptibility of alcohol/nicotine dependence in the Hispanic population.
Anna Radominska-Pandya, Ph.D. (Biochemistry and Molecular Biology)
Structure-function relationship studies of human UDP-glucuronosyltransferases (UGTs); Transcriptional regulation of UGTs via environmental pollutants; Role of UGTs in breast cancer and in cancer prevention; and Detoxification of drugs and endogenous compounds
Nancy J. Rusch, Ph.D. (Pharmacology, Interdisciplinary Toxicology)
Katharine E. Stewart, Ph.D., M.P.H. (Health Behavior and Health
Behavioral science approaches to reducing sexual health risk; improving outcomes in
HIV-positive patients and persons with other chronic illnesses, and addressing
racial health disparities in sexual and reproductive health.
Galen Wenger Ph.D. (Pharmacology & Toxicology)
My research interests are in the measurement of cognitive function in laboratory
animals, the effects of drugs of abuse on cognitive function, and the effect of
cognitive enhancers in a mouse model of Down syndrome.
William D. Wessinger, Ph.D. (Pharmacology, Interdisciplinary
Toxicology) Web profile
My research interests are in the behavioral pharmacology
of drug abuse and the mechanisms of drug dependence and addiction. We are
currently conducting research to test antibody-based medications designed to
stop or prevent methamphetamine self-administration and/or relapse to
Delia West, Ph.D. (Health Behavior & Health Education)
Obesity treatment and prevention, particularly treatment outcome studies
which often target populations with obesity-related comorbidities such as
type 2 diabetes. Research conducted in community-based settings or
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