Jerry Ware

Professor
Ph.D., University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab:  (501) 526-7528
Email:  jware@uams.edu  

Dr. Ware’s laboratory studies fundamental aspects of platelet biology to elucidate their role of in hemostasis, thrombosis and in the development of cardiovascular disease. Since platelets are anucleate fragments of cytoplasm, in vivo models are used based on the hypothesis that the unique cellular characteristics of megakaryocytes and platelets require the correct in vivo environment for meaningful assessment of biological properties. Currently, we are characterizing variants of the human glycoprotein Ib receptor expressed on the surface of circulating mouse platelets. Methodologies include the generation of transgenic and gene-targeted deletions in the mouse genome. These studies are defining the molecular mechanisms controlling normal platelet generation and the role of specific platelet receptors in disease.

Representative Publications

Boilard, E., Nigrovic, P, Larabee, K., Coblyn, J.S., Weinblatt, M.E., Massarotti, E.M., Remold-O’Donnel, E., Farndale, R.W., Ware, J., Lee, D.M.  2010  Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.  Science 327:580-583. (see Commentary in the same issue, pg 528-529)  

Schmaier, A.A., Zou, Z., Kazlauskas, A., Emert-Sedlak, L., Fong, K.P., Neeves, K.B., Maloney, S.F., Diamond, S.L., Kunapuli, S.P., Ware, J., Brass, L.F., Smithgall, T.E., Saksela, K., and Kahn, M.L.  2009  Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.  Proc Natl Acad Sci USA, 106:21167-21172. 

Guerrero, J.A., Kyei, M., Russell, S., Liu, J., Gartner, T.K., Storrie, B., and Ware, J.  2009  Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.  BLOOD, 114:5541-5546. (Cover Art for the same issue)  

Fontana, G., Ware, J., and Cattaneo, M. 2009  Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis.  Haematologia, 94:581-584.

Jain, S., Russell, S., and Ware, J. 2009 Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models. J Thromb Haemost. 7:1713-1717. (see Commentary in the same issue, pg 1712)

Suva, L.J., Hartman, E., Dilley, J.D., Russell, S., Akel, N.S., Skinner, R.A., Budde, U., Varughese, K.I., Kanaji, T. and Ware, J.  2008  Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathology, 172:430-439.

Cheli, Y., Jensen, D., Marchese, P., Habart, D., Wiltshire, T., Cooke, M., Fernandez, J.A., Ware, J., Ruggeri, Z.M. and Kunicki, T.J.  2008  The Modifier of Hemostasis (MH) locus on mouse chromosome 4 controls in vivo hemostasis of Gp6-/- mice.  BLOOD, 111:1266-1273.

Guerrero, J.A., Shafirstein, G., Russell, S., Kanaji, T., Liu, J., Gartner, T.K., Baumler, W., Jarvis, G.E. and Ware, J.  2008 In vivo relevance for platelet glycoprotein Ibα Tyr276 in thrombus formation. J Thromb Haemost.,  6:684-691.

Liu, J., Joglekar, M., Ware, J., Fitzgerald, M.E.C., Lowell, C.A., Berndt, M.C., and Gartner, T.K.  2008 Evaluation of the physiological significance of botrocetin/von Willebrand factor in vitro signaling.  J Thromb Haemost.,  6:1915-1922. 

Nishikii, H., Eto, K., Tamura, N., Hattori, K., Heissig, B., Kanaji, T., Sawaguchi, A., Goto, S., Ware, J. and Nakauchi, H.  2008  Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.  J Exp Medicine, 208:1917-1927. (see Commentary in same issue, pg 1717.

Link to Dr. Ware at PubMed

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