Michael E. Soulsby
Associate Professor
Ph.D., West Virginia University
Office: (501) 686-5127
Lab: (501) 686-5127
Email: SoulsbyMichaelE@uams.edu

Our laboratory is interested in the influence of space travel, with its associated weightlessness, on body function. We have perfected a land-based, rat, tail-suspension model of exposure to microgravity. Using this model, we have continuously and telemetrically monitored changes in heart rate, arterial pressure, body temperature, body activity, and the electrocardiogram during weeks of suspension. We have followed circadian rhythm changes in these parameters before, during, and after suspension. We have monitored bone density loss and muscle atrophy resulting from hind limb unloading. We have studied brain stress during suspension, by measuring changes in brain lipid peroxidation. We have followed changes in pancreatic function during prolonged hind-limb suspension. Currently, we are investigating changes in vascular and intestinal smooth muscle mechanical function using this model.

Dr. Soulsby's Laboratory Homepage

Representative Publications

Chowdhury P, Soulsby M, Kyongmin K. L-carnitine influence on oxidative stress induced by hind-limb unloading in adult rats. Aviation, Space and Environmental Medicine, 78:554-556, June, 2007.

Chowdhury, P, Soulsby, M.  Oxidant/Anti-oxidant Status in Rats Exposed to Simulated Weightlessness by Hind-limb Unloading and Reloading. The Open Clinical Chemistry Journal, 1: 47-56, 2008.

Chowdhury P, ME Soulsby and JL Scott. Effects of aminoguanidine on tissue oxidative stress induced by hindlimb unloading (HLU) in rats.  Annals Clin. & Lab. Sci. 39(1): 2009.

Mehta R, Lane R, Jumper H, Kitchens M.C., Ali N, Soulsby M.E., Chowdhury P. Studies of Hard and Soft Tissue Elemental Compositions in Mice and Rats Subjected to Simulated Microgravity. American Journal of Physics (TBA).

Rahul Mehta., Alec Watson., Nawab Ali., Michael Soulsby, Parimal Chowdhury. Analysis of 20 KEV electron induced X-ray production in skull femur/tibia bones of rats. 4th BioNanoTox,Biology, Nanotechnology, Toxicology and Applications; November 4-5, 2009; Little Rock, Arkansas. New York: American Institute of Physics ( AIP Proceedings); April 12, 2010. volume 1229, pp73-79 p

Link to Dr. Soulsby at Pub-Med

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