Rosalia C. M. Simmen, Ph.D.
Professor
Ph.D., University of Hawaii
Office:  501-364-2849
Email: SimmenRosalia@uams.edu

Research in my laboratory is focused on the regulators of gene expression in the mammary gland and uterus that are essential for these tissues’ proper function and development. We seek to understand how steroid hormones and extra-cellular factors including growth factors and dietary components regulate the normal (and abnormal as in tumorigenesis) development of these tissues and to characterize the key gene products and signaling molecules that mediate these events. We use a variety of in vivo and in vitro models in our studies. We also use diverse cellular and molecular techniques including gene arrays for gene discovery, cell lines for analyzing signaling pathways, and rats and mouse mutants for studying in vivo gene regulation.  The aim of all these studies is to provide important insights into regulatory mechanisms that control tissue growth and development in the whole animal.

Dr. Simmen's Laboratory Homepage

Arkansas Children's Nutrition Center

 Representative Publications

Rahal, O. and Simmen, R.C.M.  2010.  PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. Carcinogenesis 131(8): doi:10.1093/carcin/bgq123.

Pabona, J.M.P., Zeng, Z., Simmen F.A. and Simmen, R.C.M.  2010.  Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Krüppel-like factor (KLF) family members KLF9 and KLF13.  Endocrinology 151(7):3396-406.

Simmons, C.D., Pabona, J.M.P., Zeng, Z, Velarde, M.C., Gaddy. D., Simmen, F.A., and Simmen, R.C.M.  2010.  Response of adult mouse uterus to early disruption of estrogen receptor-α signaling is influenced by Krüppel-like factor 9. J Endocrinology 205: 147-157.

Su, Y. and Simmen, R.C.M.  2009.  Soy isoflavone genistein  upregulates epithelial adhesion molecule E-cadherin expression and attenuates β-catenin signaling in mammary epithelial cells. Carcinogenesis 30: 331-339.

Su, Y., Shankar, K. and Simmen, R.C.M.  2009.  Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr 139: 945-951.

Velarde, M.C., Zeng, Z., McQuown, J.R., Simmen, F.A. and Simmen, R.C.M.  2007.  Krüppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor α signaling in Ishikawa endometrial adenocarcinoma cells.  Mol Endocrinol  21: 2988-3001.

 

Link to Dr. Simmen at Pub-Med

Link to Dr. Mercado-Simmen at Pub-Med

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