Rosalia C. M. Simmen, Ph.D.
Professor
Ph.D., University of Hawaii

Research in my laboratory is focused on the regulators of gene expression in the mammary gland and uterus that are essential for these tissues’ proper function and development. We seek to understand how steroid hormones and extra-cellular factors including growth factors and dietary components regulate the normal (and abnormal as in tumorigenesis) development of these tissues and to characterize the key gene products and signaling molecules that mediate these events. We use a variety of in vivo and in vitro models in our studies. We also use diverse cellular and molecular techniques including gene arrays for gene discovery, cell lines for analyzing signaling pathways, and rats and mouse mutants for studying in vivo gene regulation.  The aim of all these studies is to provide important insights into regulatory mechanisms that control tissue growth and development in the whole animal.

Dr. Simmen's Laboratory Homepage

Arkansas Children's Nutrition Center

 Representative Publications

Su, Y., Simmen, F.A., Xiao, R. and Simmen, R.C.M.  2007.  Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors.  Physiol Genomics 30:8-16

Velarde, M.C., Zeng, Z., McQuown, J.R., Simmen, F.A. and Simmen, R.C.M.  2007.  Krüppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor α signaling in Ishikawa endometrial adenocarcinoma cells.  Mol Endocrinol 21: 2988-3001.

Zeng Z, Velarde MC, Simmen FA, Simmen RCM.  2008.  Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor-9.  Biol Reprod. 78: 1029-1037.

Simmen FA, Su Y, Xiao R, Zeng Z, Simmen RCM. 2008. The Krüppel-like factor-9 (KLF9) network in HEC-1A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol Endocrinol 6: 41. 

Pabona JMP, Velarde MC, Zeng Z, Simmen FA, Simmen RCM. 2009. Nuclear receptor co-regulator Krüppel-like factor-9 and prohibitin 2 expression in oestrogen-induced epithelial cell proliferation in the mouse uterus. J Endocrinol 200: 63-73.

Su Y, Simmen RCM. 2009 Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates β-catenin signaling in mammary epithelial cells.  Carcinogenesis doi:10.1093/carcin/bgn279.

 

Link to Dr. Simmen at Pub-Med

Link to Dr. Mercado-Simmen at Pub-Med

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