 |
|
|
 Frank
A. Simmen
Professor
Ph.D., Biochemistry, University of Hawaii
Office: (501) 686-8128
Email: simmenfranka@uams.edu
There are two research areas ongoing in our
laboratory. In the first, we are studying the molecular mechanisms by
which the uterus and embryo communicate (embryo-maternal cross-talk).
This involves studies of growth factors and transcription factors and
their molecular mechanisms of action. In the
second area, we
are studying how nutritional factors affect gene expression in the
gastrointestinal tract and with long-lasting effects on cancer
pre-disposition. Experimental models and approaches used include in
vitro tissue and cell models, molecular & cell biology, and genomics.
Representative Publications
Simmen, F.A., Xiao, R., Velarde, M.C., Nicholson, R.D.,
Bowman, M.T., Fujii-Kuriyama, Y., Oh, S.P. and Simmen, R.C.M.
Dysregulation of intestinal crypt cell proliferation and villus cell
migration in mice lacking Krüppel-like Factor 9. Am. J. Physiol.
Gastrointest. Liver Physiol., Vol. 292, 2007, pp. G1757-G1769.
Su, Y., Simmen, F.A., Xiao, R. and Simmen,
R.C.M. Expression profiling of rat mammary epithelial cells reveals
candidate signaling pathways in dietary protection from mammary tumors.
Physiological Genomics, Vol. 30, 2007, pp. 8-16.
Xiao, R., Hennings, L.J., Badger, T.M. and
Simmen, F.A. Fetal programing of colon cancer in adult rats:
correlations with altered neonatal growth trajectory, circulating IGF-I
and IGF binding proteins, and testosterone. J. Endocrinol., Vol.
195(1), 2007, pp. 79-87.
Velarde, M.C., Zeng, Z., McQuown, J.R., Simmen,
F.A. and Simmen, R.C.M. Krüppel-like Factor 9 is a negative
regulator of ligand-dependent estrogen receptor α signaling in Ishikawa
endometrial adenocarcinoma cells. Mol. Endocrinol., Vol. 21, 2007, pp.
2988-3001.
Xiao, R., Su, Y., Simmen, R.C.M. and Simmen, F.A.
Dietary soy protein inhibits DNA damage and cell survival of colon
epithelial cells through attenuated expression of fatty acid synthase.
Am. J. Physiol. Gastrointest.
Liver Physiol., Vol. 294, 2008, pp. G868-G876.
Zeng, Z., Verlarde, M.C., Simmen, F.A. and
Simmen, R.C.M.
Delayed parturition and altered
myometrial progesterone receptor isoform A expression in mice null for
Krüppel-like Factor 9. Biol. Reprod., Vol. 78(6), 2008, pp. 1029-1037.
Simmen, F.A., Su, Y., Xiao, R., Zeng, Z. and
Simmen, R.C.M. The Krüppel-like Factor 9 (KLF9) network in HEC-1-A
endometrial carcinoma cells suggests that carcinogenic potential of dys-regulated
KLF9 expression. Reprod. Biol. & Endocrinol., Vol. 6:41, 2008.
Pabona, J.M.P., Velarde, M.C., Zeng, Z., Simmen, F.A. and
Simmen,
R.C.M. Nuclear receptor co-regulator Krüppel-like factor 9 and
prohibitin 2 expression in oestrogen-induced epithelial cell
proliferation in
the mouse uterus. J. Endocrinol., Vol. 200(1), 2009, pp. 63-73.
Link
to Dr. Simmen at Pub-Med
Questions about this page? Send us an email.
All contents © 2000-2006.
UAMS Online
Copyright
Statement
Privacy Statement
updated
12/20/06
|
|
