Marina V. Mikhailova
                                                           Research Assistant Professor
                                                           Ph.D., Moscow State University

                                                           Office:  (501)-526-7575
                                                           Email:  mikhailovamarinav@uams.edu

Dr. Mikhailova has recently joined Dr. Lawrence Cornett’s laboratory, where she participates in two ongoing research projects. The first one is focused on the role of membrane-bound vasotocin receptors in response to stress in birds. This includes the VT2 receptor, previously cloned in this laboratory, and the VT3 receptor, the avian analog of human oxytocin receptor. The main interest is to study how VT2 receptor may mediate the stimulatory effect of arginine vasotocin on adrenocorticotropin hormone secretion in birds. The second is a collaborative research project with Arkansas Children’s Hospital on beta2-adrenergic receptor.  This membrane protein plays an essential regulatory role in a variety of cells, and is an important therapeutic target in the treatment of airway and cardiovascular diseases. The purpose of this work is to develop a useful gene delivery model for increased expression of the beta2-adrenergic receptor utilizing an adeno-associated viral vector.

 Dr. Mikhailova’s previous studies were linked to another group of membrane-associated proteins, chloride channels in the kidney. As reflected in the publications below, her research interest has been the molecular cloning and expression of chloride channels in basolateral membranes of the Henle’s loop thick ascending limb of the nephron.

 Representative Publications

Mikhailova, M.V., P. Mayeux, A. Jurkevich, W.J. Kuenzel, A. Periasamy, Y. Chen, and L.E. Cornett (2007) Hetero-oligomerization between vasotocin and corticotrophin-releasing hormone (CRH) receptors augments CRH-stimulated cyclic AMP production. Molec. Endocrinol. 21:2178-2188.

Gubrij, K.I., Chaturvedi C.M., Ali, N., Cornett, L.E., Kirby, J.D., Wilkerson, J., Mikhailova, M., Turner, M.L., Baeyens, D.A. Molecular cloning of an oxitocin-like receptor expressed in the chicken gland. (2005) Comparative Biochem. Physiol. 142: 37-45.

Winters, C.J., Mikhailova M.V, Andreoli T.E. Cl- channels in basolateral TAL membranes. XIX.Cytosolic Cl^-  regulates mmClC-Ka and mc-ClC-Ka channels. (2003) J. Biol.Membr.,Sep. 195.

Mikhailova M.V, Winters, C.J., Andreoli T.E. Cl- channels in basolateral TAL membranes. XVI. MTAL and CTAL cells each contain the mRNAs encoding mmClC-Ka and mcClC-Ka. (2002) Kidney Int. Mar;61(3):1003-10

 Basnakian, A.G, Ueda, N., Kaushal, G.P. , Mikhailova, M.V. and Shah, S.V. DNase I-like endonuclease in rat kidney cortex activated during ischemia/reperfusion injury (2002) Kidney Int.Apr.13(4): 1000-7.

 Winters,C.J., Zimniak, L., Mikhailova, M.V., Reeves, W.B., Andreoli, T.E..Cl-Channels in basolateral TAL membranes. XV. Molecular heterogeneity between cortical and medullary channels (2000) J. Biol. Membr., 177:221-230.

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