Division of Endocrinology and Metabolism (link)

Adler RA., Curtis JR., Saag K., Weinstein RS. Glucocorticoid-Induced Osteoporosis. In Marcus R, Feldman D, Nelsen DA, Rosen CJ (eds) Osteoporosis 3rd Edition ed. Elsevier, Amsterdam: 2008. Chapter 1135-1166.

Aguirre JI, Plotkin LI, Gortazar AR, Millan MM, O'Brien CA, Manolagas SC, Bellido T. A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction. J Biol Chem 2007 Aug; 282(35):25501 - 25508.

Ahmed HN., Chhaya SK., Makdissi A., Zimmerman RS. Diabetic muscle infarction: case report of a rare complication. Am J Med 2007 Jul; 120(7):e3-5.

Almeida M;Han L;O'Brien CA;Kousteni S;Manolagas SC; Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha. Endocrinology 2006 Apr 147 (4): 1986 - 1996.

Almeida M;Han L;Martin-Millan M;Plotkin LI;Stewart SA;Roberson PK;Kousteni S;O'Brien CA;Bellido T;Parfitt AM;Weinstein RS;Jilka RL;Manolagas SC; Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007 Sep 14 282 (37): 27285 - 27297.

Almeida M;Han L;Martin-Millan M;O'Brien CA;Manolagas SC; Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem 2007 Sep 14 282 (37): 27298 - 27305.

Banga A;Bodles AM;Rasouli N;Ranganathan G;Kern PA;Owens RJ; Calcium is involved in formation of high molecular weight adiponectin. Metab Syndr Relat Disord 2008 6 (2): 103 - 111.

Bansal D, Nanda A, Gupta E, Croker M, Williams M, Bacchus A, Simmons D, Erbland M.  Myxedema Coma in a Patient with Donn’s Syndrome.  Ark Med J 2006; 103 (5): 112-3.

Bellido T.  Downregulation of Sost/Sclerostin by PTH: A novel mechanism of hormonal control of bone formation mediated by osteocytes. J Musculoskelet. Neuronal Interact 2006; 6:358-9.

Bellido T. Summary – Osteocyte control of bone formation via Sost/sclerostin. J Musculoskelet Neuronal Interact 2006; 6:360-3.

Bellido T. The osteocyte: The “third” cell of bone gets to center stage (Report from the 28th annual meeting of the American Society for Bone and Mineral Research). BoneKEy-Osteovision 2006; (11) 14-50.

Billow A. Ahmed ., Brandon C. Jeffus., Syed I. A. Bukhari., Justin T. Harney., Resat Unal., Vladimir V. Lupashin., Peter van der Sluijs. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. J Biol Chem. 2008 April; 283(14):9388-9398.

Bodles AM, Banga A, Rasouli N, Ono F, Kern PA, Owens RJ. Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes. Am J Physiol Endocrinol Metab 2006; 291(5):E1100-E1105.

Bodles AM, Varma V, Yao-Borengasser A, Phanavanh B, Peterson CA, McGehee RE, Jr., Rasouli N, Wabitsch M, Kern PA. Pioglitazone induces apoptosis of macrophages in human adipose tissue. J Lipid Res 2006;47(9):2080-8.

B. Brenner., J. T. Harney., B. A. Ahmed., B. C. Jeffus., R. Unal., J. L. Mehta., F. Kilic. Plasma serotonin levels and the platelet serotonin transporter. J Neurochem. 2007 July; 102(1):206-15.

Chen XD;Dusevich V;Feng JQ;Manolagas SC;Jilka RL; Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res 2007 Dec 22 (12): 1943 - 1956.

Choksi P, Thomas R, Simmons DL. Charcot arthropathy. An often overlooked complication of diabetes mellitus. J Ark Med Soc 2007; 103(9):229-31.

Chu WS, Das SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, McCarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E, Elbein SC. Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes 2007; 56(3):856-62.

Craig RL, Chu WS, Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab 2007; 90(3):338-44.

Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI, Zeggini E, Hasstedt SJ, Elbein SC. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes 2006; 55(9):2631-9.

Das SK, Elbein SC. The Genetic Basis of Type 2 Diabetes. Cellscience Reviews. 2006; 2:100-131.

Das SK. Genetic Epidemiology of adult onset Type 2 Diabetes in Asian Indian Population: Past, Present and Future. Int J Hum Genet [Special Issue on: Epidemiology of Genetic Diseases in India]. 2006; 6(1):1.

Das SK. Thr394Thr polymorphism (rs2970847) of PPARGC1A gene and obesity in Asian Indians. Int J Obes (Lond). 2007; 31(3):562-3.

Das SK, Elbein SC.  The search for type 2 diabetes susceptibility loci: the chromosome 1q story. Curr Diab Rep 2007; 7(2):154-64.

DAS SK., Chu WS., Mondal AK., Sharma NK., Kern PA., Rasouli N., Elbein SC. Effect of Pioglitazone Treatment on Endoplasmic Reticulum Stress Response in Human Adipose and in Palmitate Induced Stress in Human Liver and Adipose Cell Lines. Am J Physiol Endocrinol Metab 2008 Jun; 295(2):393-400.

DAS SK;Sharma NK;Chu WS;Wang H;Elbein SC; Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. BMC Med Genet 2008; 9, 16.

DAS SK;Chu WS;Mondal AK;Sharma NK;Kern PA;Rasouli N;Elbein SC; Effect of Pioglitazone Treatment on Endoplasmic Reticulum Stress Response in Human Adipose and in Palmitate Induced Stress in Human Liver and Adipose Cell Lines. Am J Physiol Endocrinol Metab 2008 Jun 10.

Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, Kao WH. Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes. Diabetes 2006; 55(10):2909-14.

Elbein SC, Wang X, Karim MA, Chu WS, Silver KD. Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects. BMC Med Genet 2006; 7:62.

Elbein SC;Chu WS; DAS SK;Yao-Borengasser A;Hasstedt SJ;Wang H;Rasouli N;Kern PA; Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia 2007 Aug 50 (8): 1621 - 1630.

Elbein SC; Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations. Curr Opin Clin Nutr Metab Care 2007 Jul 10 (4): 415 - 419.

Elbein SC;Rasouli N; Intermuscular lipid: a marker of disordered fat partitioning or the consequence of obesity?. Am J Clin Nutr 2008 Jun 87 (6): 1585 - 1586.

Faas F. Clinical Obstetrics: The Fetus and Mother. Third edition ed. Malden, MA: Blackwell Publishing; 2007. Chapter 42. Endocrine Disorders in Pregnancy.

Fu Q, Manolagas SC, O'Brien CA. Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol 2006; 26(17):6453-68.

Galli C., Zella LA., Fretz JA., Fu Q., Pike JW., Weinstein RS., Manolagas SC., O'Brien CA. Targeted deletion of a distant transcriptional enhancer of the RANKL gene reduces bone remodeling and increases bone mass. Endocrinology 149:146-153 2007 .

Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA. Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass. Endocrinology 2008 Jan; 149(1):146 - 153.

Govindarajan R, Ratnasinghe LD, Simmons DL, Siegel ER, Midathada MS, Kim L, Kim P, Owens RJ, Lang NP.  Thiazolidinediones (TZD) and the risk of lung, prostate and colon cancer in diabetic subjects. J Clin Oncol 2007; 25(12):1476-81.

Hamid Z, Simmons D. Letter to the Editor: Triple Therapy in Type 2 Diabetes: Insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naïve patients. Diabetes Care 2006; 29: 2331.

Z Hamid., Faas F. Cyclical Cushing's syndrome due to bronchial carcinoid: early diagnosis and prompt treatment. Cyclical Cushing's syndrome 2008 April; 18(2):95-100.

Hasstedt SJ;Chu WS;DAS SK;Wang H;Elbein SC; Type 2 diabetes susceptibility genes on chromosome 1q21-24. Ann Hum Genet 2008 Mar 72 (Pt 2): 163 - 169.

Ioachimescu AG., Makdissi A., Lichtin A., Zimmerman RS. Thyroid Disease in Patients with Immunologic Thrombocytopenia: a Cohort Study. Thyroid 2007 Nov; 17(11):1173-42.

Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology 2006; 147(12):5592-9.

Jilka RL;Weinstein RS;Parfitt AM;Manolagas SC; Quantifying osteoblast and osteocyte apoptosis: challenges and rewards. J Bone Miner Res 2007 Oct 22 (10): 1492 - 1501.

Jilka RL; Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 2007 Jun 40 (6): 1434 - 1446.

Jilka RL., Bellido T., Almeida M., Plotkin LI., O'Brien CA., Weinstein RS., Manolagas SC. (In Press). Principles of Bone Biology. 3rd ed. New York: Academic Press, Inc.; 2008. Chapter 13. Apoptosis of Bone Cells.

      1.            Jilka RL, O’Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC. Intermittent PTH Stimulates Periosteal Bone Formation by Actions on Post-mitotic Preosteoblasts. Bone, [Epub ahead of print] 2008.

Karim MA, Craig RL, Wang X, Hale TC, Elbein SC. Analysis of FOXO1A as a candidate gene for type 2 diabetes. Mol Genet Metab 2006; 88(2):171-7.

Kern PA, Rasouli N. The pathogenesis and treatment of high-risk obesity.  In: Fonseca V, editor.  Clinical Diabetes. Philadelphia, PA: Saunders; 2006.

Kern PA.  Adipose tissue gene expression in the context of inflammation and obesity. In:  Meskin MS, editor. Phytochemicals: Nutrient-gene interactions. Boca Raton: CRC Taylor & Francis; 2006. p. 83-96.

Kohli M, Viswamitraa S, Schaefer R, Faas FH, Kumar U. Metastasectomy for isolated bilateral adrenal metastases in hormone-refractory prostate cancer. Clin Adv Hematol Oncol 2006; 4(10):754-5.

Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol 2007; 27(4):1516-30.

Liu Z;Aronson J;Wahl EC;Liu L;Perrien DS;Kern PA;Fowlkes JL;Thrailkill KM;Bunn RC;Cockrell GE;Skinner RA;Lumpkin CK; A novel rat model for the study of deficits in bone formation in type-2 diabetes. Acta Orthop 2007 Feb 78 (1): 46 - 55.

Makdissi A., Zimmerman RS. Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. Endocr Pract. 2007 Jul-Aug; 13(4):389-95.

Malhotra A, Elbein SC, Ng MC, Duggirala R, Arya R, Imperatore G, Adeyemo A, Pollin TI, Hsueh WC, Chan JC, Rotimi C, Hanson RL, Hasstedt SJ, Wolford JK. Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes 2007; 56(3):890-6.

Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Response to Windahl et al. J Clin Invest 2006; 116(11):2834.

Manolagas SC, Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol 2007 Nov; 21(11):2605 - 2614.

Manolagas SC. (In Press). De-fense! De-fense! Defense: scavenging H202 while making cholesterol. Endocrinology 2008; 149(7):3267-73.

Mehta JL, Rasouli, N, Sinha AK, Molavi B. Oxidative stress in diabetes: a mechanistic overview of its effects on parthenogenesis and myocardial dysfunction. Int J Biochem Cell Biol 2006; 38(5-6):794-803.

Molavi B, Rasouli N, Kern PA. The prevention and treatment of metabolic syndrome and high-risk obesity. Curr Opin Cardiol 2006; 21(5):479-85.

John O Nyalala., Jiang Wang., An Dang., Fred H Faas., Grady Smith. Hypertriglyceridemia and hypercholesterolemia: effects of drug treatment on fatty acid composition of plasma lipids and membranes.. Prostaglandins, Leuoktrienes and Essential Fatty Acids 2008 78:271-80.

      1.            O’Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling A, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T.  Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes.  PLoS ONE, 3(8): e2942, 2008.

Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, et al. and the International Type 2 Diabetes 1q Consortium. Common variation in the LMNA gene (encoding Lamin A/C) and type 2 diabetes: association analyses in 9518 subjects. Diabetes 2007;56(3):879-83.

Pineyro MM., Makdissi A., Faiman C., Prayson RA., Reddy SK., Mayberg MC., Weil RJ., Hamrahian AH. Poor Correlation of Serum alpha-subunit concentration and magnetic resonance imaging following pituitary surgery in patients with nonfunctional pituitary macroadenomas. Endoc Pract. 2008 May-June; 14(4):452-7.

Plotkin LI, Manolagas SC, Bellido T. Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. Bone 2006; 39(3):443-52.

Plotkin LI, Manolagas SC, Bellido T. Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis. J Biol Chem 2007 Aug; 282(33):24120 - 24130.

Qiu S, Rao DS, Palnitkar S, Parfitt AM. Independent and combined contributions of cancellous and cortical bone deficits to vertebral fracture risk in postmenopausal women. J Bone Miner Res 2006; 21(11):1791-6.

Ranganathan G, Unal R, Pokrovskaya I, Yao-Borengasser A, Phanavanh B, Lecka-Czernik B, Rasouli N, Kern PA. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res 2006; 47(11):2444-50.

Rasouli N, Yao-Borengasser A, Miles LM, Elbein SC, Kern PA. Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression. Am J Physiol Endocrinol Metab 2006; 290(1):E42-E46.

Rasouli N, Kern PA, Reece EA, Elbein SC. Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes. Am J Physiol Endocrinol Metab 2007; 292(1):E359-E365.

Rasouli N, Molavi B, Elbein SC, Kern PA. Ectopic fat accumulation and metabolic syndrome. Diabetes, Obesity and Metabolism  2007; 9(1):1-10.

Rasouli N;Spencer HJ;Rashidi AA;Elbein SC; Impact of family history of diabetes and ethnicity on -cell function in obese, glucose-tolerant individuals. J Clin Endocrinol Metab 2007 Dec 92 (12): 4656 - 4663.

Robling AG, Bellido T., Turner CH. Mechanical stimulation in vivo reduces osteocyte expression of sclerostin. J Musculoskelet Neuronal Interact 2006; 6:354.

Rodriguez MC, Rani D, Faas FH. Unusual clinical course of Graves' thyrotoxicosis and concomitant sarcoidosis: case report and review of literature. Endocr Pract 2007 Mar; 13(2):159 - 163.

Sharma NK., DAS SK., Mondal AK., Hackney OG., Chu WS., Kern PA., Rasouli N., Spencer HJ., Yao-Borengasser A., Elbein SC. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab 2008 Nov; 93(11):4532-41.

Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ. A novel locus on the X chromosome regulates post-maturity bone density changes in mice. Bone 2007; 40(3):758-66.

R. Unal., B.A. Ahmed., B.C. Jeffus., J.T. Harney., C.S. Lyle., Y.-K. Wu., T.C. Chambers., E.A. Reece ., F. Kilic. At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner. J Neurochem. 2007 May; 101(4):937-948.

Unal R;Pokrovskaya I;Tripathi P;Monia BP;Kern PA;Ranganathan G; Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA. Biochem J 2008 Jul 15 413 (2): 315 - 322.

Varma V, Yao-Borengasser A, Rasouli N, Bodles AM, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ, III, McGehee RE, Jr., Fried SK, Kern PA. Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipid and inflammation. J Clin Endocrinol Metab 2007; 92(2):666-72.

Varma V;Yao-Borengasser A;Bodles AM;Rasouli N;Phanavanh B;Nolen GT;Kern EM;Nagarajan R;Spencer HJ;Lee MJ;Fried SK;McGehee RE;Peterson CA;Kern PA; Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance. Diabetes 2008 Feb 57 (2): 432 - 439.

Wang H, Elbein SC. Detection of allelic imbalance in gene expression using pyrosequencing(r). Methods Mol Biol 2007; 373:157-76.

Weinstein RS, Roberson PK, Manolagas SC. Giant Osteoclast Formation and Long-term Oral Bisphosphonate Therapy. NEJM 2009; 360:53-62.

Wright JT;Harris-Haywood S;Pressel S;Barzilay J;Baimbridge C;Bareis CJ;Basile JN;Black HR;Dart R;Gupta AK;Hamilton BP;Einhorn PT;Haywood LJ;Jafri SZ;Louis GT;Whelton PK;Scott CL;Simmons DL;Stanford C;Davis BR; Clinical outcomes by race in hypertensive patients with and without the metabolic syndrome: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med 2008 Jan 28 168 (2): 207 - 217.

Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Croce MA, Gropler MC, Varma V, Yao-Borengasser A, Rasouli N, Kern PA, Finck BN, Bickel PE. OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 2006; 55(12):3418-28.

Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ, III, McGehee RE, Jr., Reue K, Kern PA. Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes 2006; 55(10):2811-8.

Yao-Borengasser A;Varma V;Bodles AM;Rasouli N;Phanavanh B;Lee MJ;Starks T;Kern LM;Spencer HJ;Rashidi AA;McGehee RE;Fried SK;Kern PA; Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab 2007 Jul 92 (7): 2590 - 2597.

Yao-Borengasser A., Rassouli N., Varma V., Bodles AM., Rasouli N., Unal R., Phanavanh B., Ranganathan G., McGehee RE Jr., Kern PA. Stearoyl-CoA Desaturase 1 (SCD1) Gene Expression increases following pioglitazone treatment and is associated with PPAR? responsiveness in Humans.. J Clin Endocrinol Metab. 2008 August;

Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI, Vaxillaire M, Walker M, Wang X, Whittaker P, Xiang K, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, McCarthy MI. Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes 2006; 55(9):2541-8.